KMID : 0882420160900010063
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Korean Journal of Medicine 2016 Volume.90 No. 1 p.63 ~ p.67
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Myelodysplastic Syndrome and Minimal Change Nephrotic Syndrome treated with Steroid Challenge
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ÀÌ»ó¾Æ:Lee Sang-Ah
ÀÓÀåȯ:Lim Jang-Hwan/ÀåÁöÈÆ:Jang Ji-Hun/Àå¼øÈñ:Chang Soon-Hee/°ûÀº°æ:Kwak Eun-Kyoung/ÀÌ´öÇö:Lee Duck-Hyun/À̼±¾Æ:Lee Sun-Ah
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Abstract
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Glomerulonephritis associated with malignancy is deemed to be paraneoplastic glomerulonephritis. Myelodysplastic syndrome (MDS) is a group of heterogeneous clonal hematopoietic stem cell disorders characterized by impaired hematopoietic cell differentiation and cytopenia. The pathophysiology of MDS is thought to be immune-mediated in part. A few reports have documented various forms of glomerulonephritis in patients with MDS and suggested that immune dysregulation is important in the development of paraneoplastic glomerulonephritis. Here, we report a patient with MDS and refractory anemia with excess blast-2 accompanied by minimal change nephrotic syndrome. The patient was treated with prednisolone, and the nephrotic-range proteinuria and pancytopenia improved markedly.
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KEYWORD
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Myelodysplastic syndromes, Nephrotic syndrome, Steroids
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